Experimental hypersensitivity pneumonitis: role of MCP-1
نویسندگان
چکیده
منابع مشابه
Genetic control of experimental murine hypersensitivity pneumonitis.
lenged with PDE developed extensive interstitial infiltrations of macrophages and multinucleated giant cells that were most prominent around respiratory bronchioles but also extended into the alveolar septa. There were also associated perivascular lymphocytic and plasma cell infiltrates. Neither immunization nor aerosol challenge per se resulted in pulmonary inflammation. In contrast, C57BL/10 ...
متن کاملHypersensitivity pneumonitis
PURPOSE OF REVIEW To bring readers up to date on recent reports, both clinical and basic understanding, on hypersensitivity pneumonitis. RECENT FINDINGS Although many antigens and environmental settings have already been described as sources of this hyperimmune pulmonary disease, the literature continues to bring forth other conditions that can cause hypersensitivity pneumonitis. We also high...
متن کاملHypersensitivity pneumonitis.
Clinical manifestations of hypersensitivity pneumonitis may closely mimic other interstitial lung diseases, and the disease onset is usually insidious. High-resolution computed tomography and bronchoalveolar lavage are the sensitive and characteristic diagnostic tests for hypersensitivity pneumonitis. The relevant antigen to hypersensitivity pneumonitis cannot be identified in up to 20% to 30% ...
متن کاملPathology of hypersensitivity pneumonitis.
PURPOSE OF REVIEW Hypersensitity pneumonitis, caused by inhalation of various antigens, is characterized by interstitial mononuclear cell infiltration, nonnecrotizing granulomas, cellular bronchiolitis, and fibrosis. The pathological picture of chronic hypersensitivity pneumonitis is, however, complicated; it is sometimes difficult to differentiate chronic hypersensitivity pneumonitis from idio...
متن کاملInterleukin-17-mediated immunopathogenesis in experimental hypersensitivity pneumonitis.
RATIONALE T cells play a critical role in the development of Saccharopolyspora rectivirgula-induced hypersensitivity pneumonitis (HP) but little is known about the role of IL-17A in this disease. OBJECTIVES We examined the role of IL-17A in a murine model of S. rectivirgula antigen (SR-Ag)-induced HP. METHODS Experimental HP was induced by oropharyngeal instillation of SR-Ag in wild-type an...
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ژورنال
عنوان ژورنال: Journal of Laboratory and Clinical Medicine
سال: 2003
ISSN: 0022-2143
DOI: 10.1016/s0022-2143(03)00107-0